Fecha de registro: 18 may 2022



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24 - rar. GNU General Public License. Detailed information and free download links are available at the site GNU. Influence of intravenous and local administration of L-NAME on the rabbit corneal reflex. This study aimed to evaluate the effect of an intraocular pressure (IOP) on the rabbit corneal reflex (CR) and evaluate the effect of the nitric oxide (NO) antagonist L-NAME on the CR, when administered systemically (i.v.) or locally into the eye. The corneal reflex, an ocular reflex, that occurs in response to mechanical stimulation of the ocular surface was observed in 10 rabbits using anesthetized methods, previously treated with topical anesthesia. Ten rabbits were injected with 2 ml of physiological solution, and 10 with 5 ml of an N(ω)-nitro-L-arginine methyl ester (L-NAME) solution; they were then placed in a cage, and their corneal reflex was observed over a period of 30 min. We compared the CR-IOP curves of the animals that received systemic or local administration of L-NAME. IOP of the cornea was significantly lower in the animals that received systemic administration of L-NAME (p=0.000), but there was no significant difference in the CR-IOP curves between systemic administration of L-NAME or physiological saline in rabbits. The corneal reflex in the animals that received local administration of L-NAME was significantly higher than the animals that received systemic administration (p=0.000). Our results indicate that NO participates in the CR of rabbits, and L-NAME inhibited the CR locally, but not systemically, in rabbits.Electron transfer from thiocarbonyl compounds to cytochrome c and reaction with Cys-151 in horseradish peroxidase. Thiocarbonyl compounds and their analogs were studied for their effects on electron transfer from horseradish peroxidase to the heme iron of cytochrome c. The dithiocarbamates were found to be electron acceptors, leading to the formation of a complex between the peroxidase and the cytochrome. When the peroxidase was inactivated, the complex was characterized by a change in the absorption of the peroxidase, as well as a decrease in the electrochemical signal. The amino acid composition of the peroxidase was not altered by


Asociación de daño cerebral adquirido

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